Substance P in brain extracts
نویسندگان
چکیده
منابع مشابه
Substance P in traumatic brain injury.
Recent evidence has suggested that neuropeptides, and in particular substance P (SP), may play a critical role in the development of morphological injury and functional deficits following acute insults to the brain. Few studies, however, have examined the role of SP, and more generally, neurogenic inflammation, in the pathophysiology of traumatic brain injury and stroke. Those studies that have...
متن کاملSubstance-P pathways in rat brain.
The characterization and subsequent availability of synthetic substance P has renewed interest in the role of this undecapeptide in central-nervous-system function (Mroz & Leeman, 1974). Biochemical and electrophysiological studies have demonstrated that substance P may function as an excitatory transmitter in primary sensory neurons terminating in the spinal cord (Otsuka & Konishi, 1975). In t...
متن کاملThe Role of Substance P in Ischaemic Brain Injury
Stroke is a leading cause of death, disability and dementia worldwide. Despite extensive pre-clinical investigation, few therapeutic treatment options are available to patients, meaning that death, severe disability and the requirement for long-term rehabilitation are common outcomes. Cell loss and tissue injury following stroke occurs through a number of diverse secondary injury pathways, whos...
متن کاملOntogeny of substance P receptor binding sites in rat brain.
The ontogeny of substance P (SP) receptor binding sites in rat brain has been studied using both membrane binding assays and in vitro receptor autoradiography. The density of SP binding sites is maximal 1 d before birth and decreases thereafter to reach adult values 14 d after birth. During the early postnatal period, the distribution of SP binding sites undergoes major modifications. For examp...
متن کاملIdentification of substance P precursor forms in human brain tissue.
Substance P prohormones were identified in the caudate nucleus, hypothalamus, and substantia nigra of human brain. A polypeptide fraction of acidic brain extracts was fractionated on Sephadex G-50. The lyophilized fractions were sequentially treated with trypsin and a substance P-degrading enzyme with strong preference toward the Phe7-Phe8 and Phe8-Gly9 bonds. The released substance P(1-7) frag...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1964
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1964.sp007314